RUNX2 Mouse Monoclonal Antibody [Clone ID: 1D2]

Specifications

Product Data
Clone Name	1D2
Applications	ELISA, IF, IHC, WB
Recommend Dilution	ELISA. Immunofluorescence: 10 µg/ml. Immunohistochemistry on Paraffin Sections: 5 µg/ml. Western Blot.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Partial Recombinant RUNX2 (NP_004339, 251 a.a. ~ 351 a.a) protein with GST tag.
Specificity	Recognizes Runt-related Transcription Factor 2 (RUNX2).
Formulation	PBS, pH 7.2 State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein A Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Gene Name	runt related transcription factor 2
Database Link	Entrez Gene 860 Human UniProt ID Q13950
Background	RUNX family members are DNA-binding proteins that regulate the expression of genes involved in cellular differentiation and cell cycle progression. RUNX2 is essential for skeletal mineralization in that it stimulates osteoblast differentiation of mesenchymal stem cells, promotes chondrocyte hypertrophy and contributes to endothelial cell migration and vascular invasion of developing bones. Regulating RUNX2 expression may be a useful therapeutic tool for promoting bone formation. Mutations in the C-terminus of RUNX2 are associated with cleidocranial dysplasia syndrome, an autosomal-dominant skeletal dysplasia syndrome that is characterized by widely patent calvarial sutures, clavicular hypoplasia, supernumerary teeth, and short stature.
Synonyms	Runt-related transcription factor 2, Acute myeloid leukemia 3 protein, AML3, AML-3, CBFA1, OSF2, OSF-2, PEBP2A, PEA2-alpha A, PEBP2-alpha A
Reference Data
Protein Families	Druggable Genome, Transcription Factors

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