Insulin (INS) Mouse Monoclonal Antibody [Clone ID: ISL-8J]

Specifications

Product Data
Clone Name	ISL-8J
Applications	IHC
Recommend Dilution	Immunohistochemistry on Paraffin Sections: Use at 0.4-1 μg/ml to detect Insulin in formalin fixed and paraffin embedded tissues.
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Specificity	This antibody recognizes Insulin.
Formulation	1.2% Sodium Acetate, with 2mg BSA and 0.01mg Sodium Azide State: Purified State: Lyophilized purified IgG fraction
Reconstitution Method	Restore with 1.2% Sodium Acetate or neutral PBS
Concentration	0.1 mg/ml (after reconstitution with 1ml PBS)
Purification	by goat anti-mouse IgG affinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody after reconstitution at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	insulin
Database Link	Entrez Gene 3630 Human UniProt ID P01308
Background	Insulin, synthesized by the beta cells of the islets of Langerhans, consists of 2 dissimilar polypeptide chains, A and B, which are linked by 2 disulfide bonds. The insulin gene contains 3 exons and 2 introns; exon 2 encodes the signal peptide, the B chain, and part of the C peptide, while exon 3 encodes the remainder of the C peptide and the A chain. Localization of the human insulin gene to the distal end of the short arm of chromosome 11. Harper et al. (1981) and Harper and Saunders (1981) assigned the insulin gene to 11p15.5 by in situ hybridization.
Synonyms	INS
Reference Data
Protein Families	Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein
Protein Pathways	Insulin signaling pathway, Maturity onset diabetes of the young, mTOR signaling pathway, Oocyte meiosis, Progesterone-mediated oocyte maturation, Prostate cancer, Regulation of actin cytoskeleton, Regulation of autophagy, Type I diabetes mellitus, Type II diabetes mellitus

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