MMP11 Mouse Monoclonal Antibody [Clone ID: 5ST-4A9]

Specifications

Product Data
Clone Name	5ST-4A9
Applications	IHC
Recommend Dilution	Immunohistochemistry on Frozen Sections: 5 µg/ml (1/100). Immunohistochemistry on Paraffin Sections: 10 µg/ml (1/50). Proteinase K pretreatment for antigen retrieval is recommended. Suggested Positive Control: Placenta.
Reactivity	Human, Porcine
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length recombinant Human Stromelysin-3. Antigen, epitope: The epitope has not been further characterized.
Specificity	Monoclonal antibody 5ST-4A9 recognizes Human Stromelysin-3. SL-3 (MMP-11) was originally isolated as a breast cancer associated gene. Antigen Distribution: Specifically expressed in stromal cells of breast carcinomas.
Formulation	Stock solution contains 0.5 mg/ml IgG, PBS, pH 7.2 with 5mg/ml BSA as stabilizer and 0.01% Kathon as a preservative. State: Aff - Purified State: Lyophilized purified Ig fraction
Reconstitution Method	Restore by adding 0.5 ml distilled water
Concentration	0.5 mg/ml
Purification	Affinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store the lyophilized antibody at 2- 8°C. Following reconstitution, store at -20°C. Avoid repeated freezing and thawing.
Gene Name	matrix metallopeptidase 11
Database Link	Entrez Gene 4320 Human UniProt ID P24347
Background	The MMP stromelysin-3 shares many similarities with other MMPs but also has several unique properties. It has little expression in adult organs under normal physiological conditions but is upregulated in a number of pathological processes such as tumor invasion and may also be involved in tumor initiation. During mammalian development, ST3 is expressed in many processes involving cell migration and tissue morphogenesis, especially where cell death takes place.
Synonyms	MMP11, Stromelysin-3, SL-3, ST3, STMY3, Matrix metalloproteinase-11
Reference Data
Protein Families	Druggable Genome, Protease

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