Progesterone Receptor (PGR) (C-term) Mouse Monoclonal Antibody [Clone ID: PR-6A]

Specifications

Product Data
Clone Name	PR-6A
Applications	IHC
Recommend Dilution	Immunohistochemistry on Frozen Sections: 2 µg/ml (1/100). Immunohistochemistry on Paraffin Sections: 20 µg/ml (1/10). Proteinase K pretreatment for antigen retrieval is recommended. Suggested Positive Control: Swine Uterus
Reactivity	Chicken, Human, Rabbit
Host	Mouse
Clonality	Monoclonal
Immunogen	Peptide A922-K933. Epitope: C-terminal region.
Specificity	This antibody PR-6A recognizes the Human Progesterone Receptor in the C-terminal ligand-binding domain. Therefore, it recognizes isoforms A and B. Antigen Distribution: Nuclear hormone receptor, widely expressed.
Formulation	Stock solution contains PBS, pH 7.2 with 5 mg/ml BSA as stabilizer and 0.01% Kathon as a preservative. State: Aff - Purified State: Lyophilized purified Ig fraction
Reconstitution Method	Restore by adding 0.5 ml distilled water
Concentration	0.2 mg/ml (after reconstitution)
Purification	Affinity Chromatography
Conjugation	Unconjugated
Storage Condition	Prior to reconstitution store at 2-8°C. Following reconstitution store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	progesterone receptor
Database Link	Entrez Gene 5241 Human UniProt ID P06401
Background	The progesterone receptor is an intracellular steroid receptor that specifically binds progesterone. Expressed by a single gene (chromosome 11q22), it has two main forms, A and B, that differ in their molecular weight. It has been proposed that expression of PR determination indicates a responsive estrogen receptor (ER) pathway, and therefore, may predict likely response to endocrine therapy in human breast cancer. A number of studies have shown that PR determination provides supplementary information to ER, in predicting response to endocrine therapy as well as estimating survival. PR has proved superior to ER as a prognostic indicator in some studies. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.
Synonyms	PR, PGR, NR3C3
Reference Data
Protein Families	Druggable Genome, Nuclear Hormone Receptor, Transcription Factors
Protein Pathways	Oocyte meiosis, Progesterone-mediated oocyte maturation

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