RP105 (CD180) Mouse Monoclonal Antibody [Clone ID: G28-8]
CAT#: AM26010PU-N
RP105 (CD180) mouse monoclonal antibody, clone G28-8, Aff - Purified
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CNY 3,670.00
货期*
5周
规格
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Specifications
Product Data | |
Clone Name | G28-8 |
Applications | FC, FN, IP |
Recommend Dilution | Flow cytometry: 2 μg/ml. Immunoprecipitation. Functional application: induction of B cell proliferation. |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Human tonsillar B cells |
Specificity | This antibody detects CD180. |
Formulation | PBS with 15 mM sodium azide, approx. pH 7.4 State: Aff - Purified State: Liquid Ig fraction |
Concentration | lot specific |
Purification | Protein-A affinity chromatography (> 95% pure by SDS-PAGE) |
Conjugation | Unconjugated |
Storage Condition | Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. |
Gene Name | CD180 molecule |
Database Link | |
Background | CD180, also known as RP105 (or Bgp95, LY64) is a type I membrane glycoprotein of Toll-like receptor (TLR) family. Its cytoplasmic tail is short and unlike the TLRs, it lacks the TIR domain. CD180 expression is dependent on the coexpression of its helper molecule, MD-1 , and mirrors that of TLR4 on antigen-presenting cells. CD180 regulates recognition of LPS and signaling in B cells, via interacting directly with the TLR4 signaling complex, inhibiting its ability to bind microbial ligands. Ligation of CD180 by monoclonal antibodies leads to B cell activation, upregulation of CD80/CD86, and increase in cell size. |
Synonyms | LY64 |
Reference Data | |
Protein Families | Druggable Genome, Transmembrane |
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