FLT3 Mouse Monoclonal Antibody [Clone ID: BV10A4]
CAT#: AM26022FC-N
FLT3 mouse monoclonal antibody, clone BV10A4, FITC
Conjugation: Unconjugated PE
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CNY 3,810.00
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Specifications
Product Data | |
Clone Name | BV10A4 |
Applications | FC |
Recommend Dilution | Flow cytometry analysis of human blood cells using 4 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests. |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | BV-173 leukemic cell line |
Specificity | This antibody reacts with CD135 (FLT3, FLK2, STK-1), a 130-160 kDa type III receptor tyrosine kinase that is involved in early steps of hematopoiesis. |
Formulation | Phosphate buffered saline (PBS) Label: FITC State: Liquid purified Ig fraction Stabilizer: 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) Preservative: 15 mM sodium azide Label: Conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use. |
Conjugation | FITC |
Storage Condition | Prior to and following reconstitution store the antibody at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light. |
Gene Name | fms related tyrosine kinase 3 |
Database Link | |
Background | CD135 / FLT3, also known as FLK2 or STK-1 is a receptor tyrosine kinase that plays important roles in hematopoiesis. After binding of Flt3 ligand (FL), CD135 homodimerizes and stimulates proliferation, differentiation and protects the cell from apoptosis. The loss of CD90 and gain of CD135 expression marks the loss of self-renewal in hematopoietic stem cell population. Detectable CD135 expression appears first at low levels on the surface of primitive multilineage progenitor cells and disappears during defined stages of B-cell development, but is upregulated and maintained during maturation of monocytes. CD135 is also expressed on thymocytes, dendritic cell progenitors and on mature dendritic cells, as well as on various malignant hematopoietic cells. |
Synonyms | FL cytokine receptor, STK1 |
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