Cd4 Rat Monoclonal Antibody [Clone ID: GK1.5]
CAT#: AM26029AC-N
Cd4 rat monoclonal antibody, clone GK1.5, APC
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CNY 4,340.00
货期*
5周
规格
Specifications
Product Data | |
Clone Name | GK1.5 |
Applications | FC |
Recommend Dilution | Flow cytometry: 2 μg/ml. |
Reactivity | Mouse |
Host | Rat |
Clonality | Monoclonal |
Immunogen | Mouse CTL clone V4 cells |
Specificity | This antibody reacts with an extracellular epitope of mouse CD4 transmembrane glycoprotein (55 kDa). |
Formulation | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 Label: APC State: Liquid purified Ig fraction Label: Conjugated with cross-linked Allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography. |
Concentration | lot specific |
Conjugation | APC |
Storage Condition | Store the antibody at 2 - 8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light. |
Gene Name | CD4 antigen |
Database Link | |
Background | CD4 is a single chain transmembrane glycoprotein of immunoglobulin supergene family. In its extracellular region there are 4 immunoglobulin-like domains (1 Ig-like V-type and 3 Ig-like C2-type). The intracellular region of CD4 associates with p56Lck, a Src-like protein tyrosine kinase. It was described that CD4 segregates into specific detergent-resistant T-cell membrane microdomains. CD4 binds to MHC class II molecules (by CDR2-like region in CD4 domain 1), HIV envelope protein gp120 (by CDR2-like region in CD4 domain 1) and other ligands, such as IL-16 (by to CD4 domain 3) or L-selectin. CD4 is a co-receptor involved in immune response (co-receptor activity in binding to MHC class II molecules) and HIV infection. CD4 regulates T-cell activation, T/B-cell adhesion, T-cell diferentiation, T-cell selection and signal transduction. Defects in antigen presentation (MHC class II) cause dysfunction of CD4+ T-cells and their almost complete absence in patients blood, tissue and organs (SCID immunodeficiency). |
Synonyms | T-cell surface antigen T4/Leu-3 |
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