KIR2DL4 Mouse Monoclonal Antibody [Clone ID: mAb#33]

Specifications

Product Data
Clone Name	mAb#33
Applications	FC, FN, IF, IP
Recommend Dilution	Immunoprecipitation. Flow Cytometry:1 μg/ml. Immunocytochemistry. Functional application: Cytokine secretion studies.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	NK3.3 cells and KIR2DL4-Ig fusion protein
Specificity	This Monoclonal antibody mAb#33 (also known as mAb 33 or 33) recognizes extracellular portion of CD158d / KIR2DL4, a 45 kDa NK cell marker. Cell surface expression and function of CD158d / KIR2DL4 depends on genotype of particular individuals.
Formulation	Phosphate buffered saline (PBS), pH~7.4 State: Aff - Purified State: Liquid purified IgG fraction (> 95% pure by SDS-PAGE) Preservative: 15 mM Sodium Azide
Concentration	lot specific
Purification	Protein-A Affinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4
Database Link	Entrez Gene 3805 Human UniProt ID Q99706
Background	CD158d / KIR2DL4 is a KIR family member that shares structural features with both activating and inhibitory receptors and may mediate different functions under different circumstances. It contains cytoplasmic ITIM, suggesting inhibitory function, but also transmembrane domain similar to those of activating KIRs. It has been reported that CD158d serves as an inhibitory receptor for peripheral and uterine NK cells, but its ligation with soluble mAbs (unlike immobilized mAbs) results in activation of IFN-γ secretion. CD158d also binds both membrane form and soluble form of its ligand HLA-G.
Synonyms	KIR103AS, G9P
Reference Data

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