UBN1 (1-190) Mouse Monoclonal Antibody [Clone ID: UBN1-02]

Specifications

Product Data
Clone Name	UBN1-02
Applications	IP, WB
Recommend Dilution	Immunoprecipitation. Western blot: 1-5 μg/ml; Positive control: HeLa cell line.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant protein corresponding to amino acids 1-190 of ubinuclein 1
Specificity	This antibody recognizes N-terminal part of ubinuclein 1 (UBN1), a widely expressed nuclear and adhesion complex protein. Western blotting analysis reveals UBN1 as a 165 kDa band.
Formulation	Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 State: Aff - Purified State: Liquid Ig fraction
Concentration	lot specific
Purification	Protein-A affinity chromatography (> 95% pure by SDS-PAGE)
Conjugation	Unconjugated
Storage Condition	Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Gene Name	ubinuclein 1
Database Link	Entrez Gene 29855 Human UniProt ID Q9NPG3
Background	Ubinuclein 1 (UBN1) is a ubiquitously expressed evolutionarily conserved protein which binds to proliferation-promoting genes that are repressed by formation of senescence-associated heterochromatin foci (SAHF). Ubinuclein 1 associates with various transcription factors and with histone methyltransferase activity, is indispensable for SAHF formation and appears to be a regulator of senescence. Although in most cells ubinuclein is localized to the nucleus, in cells forming tight junctions it is recruited to the cell adhesion complexes, dependently on the cell density.
Synonyms	VT; VT4
Reference Data

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