CD3E Mouse Monoclonal Antibody [Clone ID: CRIS-7]

Specifications

Product Data
Clone Name	CRIS-7
Applications	FC, IHC
Recommend Dilution	Immunohistochemistry on Frozen Sections: ≤ 0.1 μg/ml (1:2000). Does not react with formalin fixed cells (epitope is not fixation resistant). Antibody has been described to work in FACS. Suggested Positive Control: Human tonsil.
Reactivity	Human, Monkey, Rhesus Monkey
Host	Mouse
Clonality	Monoclonal
Immunogen	Stimulated Human leukocytes
Specificity	This antibody detects Human CD3. Antigen Distribution on Isolated cells: Peripheral T cells.
Formulation	Stock solution contains 0.2 mg/ml IgG, PBS, pH 7.2 with 5 mg/ml BSA as stabilizer and 0.09% Sodium Azide as a preservative State: Aff - Purified State: Lyophilized purified Ig fraction
Reconstitution Method	Restore by adding 0.5 ml distilled water
Purification	Affinity Chromatography
Conjugation	Unconjugated
Storage Condition	Prior to reconstitution store at 2-8°C. Following reconstitution store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	CD3e molecule
Database Link	Entrez Gene 699467 MonkeyEntrez Gene 916 Human UniProt ID P07766
Background	The CD3 antigen is a protein complex composed of four distinct chains (CD3γ, CD3δ and two CD3ε) that associate with the T cell receptor (TCR) and the ζ-chain to generate an activation signal in T lymphocytes. The TCR, ζ-chain and CD3 molecules together comprise the TCR complex. The CD3γ, CD3δ and CD3ε chains are highly related cell surface proteins of the immunoglobulin superfamily containing a single extracellular immunoglobulin domain.
Synonyms	T3/Leu-4
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Hematopoietic cell lineage, Primary immunodeficiency, T cell receptor signaling pathway

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