Myeloperoxidase (MPO) Mouse Monoclonal Antibody [Clone ID: 2D4]

Specifications

Product Data
Clone Name	2D4
Applications	ELISA, IF, IHC
Recommend Dilution	Immunohistochemistry on frozen sections (starting working dilution is 1:50). Flow cytometry (starting working dilution is 1:50). Immunoassay. Immunoflourescence. The antibody is not useful for Western blotting and immunohistology on paraffin embedded sections.
Reactivity	Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Specificity	This antibody reacts with rat myeloperoxidase (MPO).
Formulation	PBS Label: Biotin State: Liquid 0.2 µm filtered Ig fraction Stabilizer: 0.1% bovine serum albumin Preservative: 0.02% sodium azide
Concentration	lot specific
Purification	Protein G
Conjugation	Biotin
Storage Condition	Store at 2 - 8 °C.
Gene Name	myeloperoxidase
Database Link	UniProt ID P05164
Background	MPO is a glycoprotein with an alpha2beta2 heteromultimer expressed in all cells of the myeloid linage. MPO is abundantly present in azurophilic granules of polymorphonuclear neutrophils. It is an important enzyme used during phagocytic lysis of engulfed foreign particles which takes part in the defense of the organism through production of hypochlorous acid (HOCl), a potent oxidant. MPO is rapidly released by activated polymorphonuclear neutrophils. Involvement of MPO has been described in numerous diseases such as atherosclerosis, lung cancer, Alzheimer's disease and multiple sclerosis. Autoimmune antibodies to MPO are involved in Wegeners disease. Since the discovery of MPO deficiency, initially regarded as rare and restricted to patients suffering from severe infections, MPO has more attracted clinical attention. In experimental studies antibodies to MPO can be used for various purposes ranging from flow cytometric analysis to detection of polymorphonuclear neutrophils in tissue sections.
Synonyms	MPO
Reference Data

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