TLR2 Mouse Monoclonal Antibody [Clone ID: TLR2.45]

Specifications

Product Data
Clone Name	TLR2.45
Applications	FN, IF, IP
Recommend Dilution	Flow cytometry: Typical starting working dilution is 1:50. Immunoflourescence: Typical starting working dilution is 1:50. Immunoprecipitation. Functional assay:  Inhibition of biological activity.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Ba/F3 cells which stably express human Flag-tagged TLR2
Specificity	Thisa ntibody recognizes human TLR2 (CD282).
Formulation	PBS State: Purified State: Liquid 0.2 µm filtered Ig fraction Stabilizer: 0.1% bovine serum albumin
Concentration	lot specific
Purification	Protein G
Conjugation	Unconjugated
Storage Condition	Store at 2 - 8 °C.
Gene Name	toll like receptor 2
Database Link	Entrez Gene 7097 Human UniProt ID O60603
Background	Toll-like receptors (TLR) are highly conserved throughout evolution and are implicated in the innate defense to many pathogens. Mammalian TLRs have been identified as type I transmembrane signaling receptors with pattern recognition capabilities. TLRs recognize pathogen-associated molecular patterns (PAMPs), expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. Among TLRs, TLR2 is an unique receptor recognizing lipoproteins of Gram-negative bacteria, several whole Gram-positive bacteria, as well as peptidoglycan, lipoteichoic acid and other bacterial cell membrane products. A functional interaction between TLR2 and TLR6 in the cellular response to various bacterial products has been discovered. Bacterial species as diverse as mycobacteria, spirochetes, mycoplasma, Staphylococcus aureus, and Streptococcus pneumoniae have all been shown to mediate cellular activation via TLR2 (CD282). TLR2 is highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Furthermore, TLR2 is detected in lung and fetal liver. In other tissues TLR2 levels are low.
Synonyms	Toll-like receptor 2
Reference Data

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