CD96 Mouse Monoclonal Antibody [Clone ID: NK92.39]

Specifications

Product Data
Clone Name	NK92.39
Applications	FC, FN
Recommend Dilution	Flow Cytometry: Use 1/50 as starting dilution. Functional Assay: Blocks binding of soluble poliovirus receptor (PVR) to NK92 cells.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Specificity	This Monoclonal antibody NK92.39 reacts with CD96, also known as T cell-activated increased late expression (Tactile).
Formulation	PBS State: Purified State: Liquid 0.2 µm filtered Ig fraction Stabilizer: 0.1% BSA
Concentration	lot specific
Purification	Protein G Chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C.
Gene Name	CD96 molecule
Database Link	Entrez Gene 10225 Human UniProt ID P40200
Background	CD96 promotes natural killer (NK) cell adhesion to target cells expressing the poliovirus receptor (PVR or CD155). Furthermore CD96 stimulates cytotoxicity of activated NK cells, and mediates acquisition of PVR from target cells. This means NK cells have due to the receptor CD96 a dual receptor system that recognizes nectins and nectin-like molecules on target cells and mediates NK cells adhesion and triggering of effector functions. As PVR is highly expressed in certain tumors, this receptor system may be critical for NK cell recognition of tumors.
Synonyms	TACTILE
Reference Data

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