CD46 (SCR2 Dom.) Mouse Monoclonal Antibody [Clone ID: M177]

CAT#: AM26248PU-N

CD46 (SCR2 Dom.) mouse monoclonal antibody, clone M177, Purified



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CNY 6,281.00


货期*
5周

规格
    • 100 ug

Product images

Specifications

Product Data
Clone Name M177
Applications ELISA, FN, IP, WB
Recommend Dilution Flow Cytometry: Stains the extracellular domain of CD46 (Ref.1,2). The typical starting working dilution is 1/10.
Functional Assays  (Ref.1,3,5-7).
Immunoassays (Ref.1).
Immunoprecipitation (Ref.1,3,4): 107 cells were lysed and immunoprecipitated with 25 µg M177 antibody and 25µg protein G-sepharose.
Western Blot: A non-reduced sample treatment and SDS-page was used. The band size is 45-70 kDa (Ref.1 and 2). The typical starting working dilution is 1/10.
Positive Control: CD46 is expressed on every cell and tissue.
Negative Control: Erythrocytes.
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen Purified MCP
Specificity
The monoclonal antibody M177 recognizes CD46, also designated membrane cofactor protein (MCP). 
The monoclonal antibody M177 reacts with the SCR2 domain.
 
Formulation PBS
State: Purified
State: Liquid 0.2 µm filtered Ig fraction
Stabilizer: 0.1% BSA
Concentration lot specific
Purification Protein G Chromatography
Conjugation Unconjugated
Storage Condition Store undiluted at 2-8°C.
DO NOT FREEZE!
Gene Name CD46 molecule
Background

CD46 is a 45-70 kDa protein with genetic and tissue-specific heterogeneity. It is expressed on every cell and tissue, with the exception of erythrocytes. CD46 serves to inhibit complement activation on host tissue. It performs this function by serving as a cofactor which binds to C3b and C4b. This binding is permitted by factor I, a serine protease of plasma, to degrade C3b and C4b and serves to protect the host cell against autologous attack. It also serves as a receptor for measles virus.
Four isoforms of CD46 predominate and arise by alternative splicing of a single CD46 gene. CD46 cDNA encodes a signal sequence followed by four complement control protein domains (also called short consensus repeats (SCR).

Synonyms TLX, MIC10
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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