PI3 Mouse Monoclonal Antibody [Clone ID: TRAB2O]

Specifications

Product Data
Clone Name	TRAB2O
Applications	ELISA, IHC, WB
Recommend Dilution	Immunoassay: The typical starting working dilution is 1/10. Western blot (non-reducing conditions): The typical starting working dilution is 1/10. Immunohistochemistry on Paraffin Sections. Not useful for Immunohistochemistry on Frozen Sections.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Specificity	TRAB2O recognises all known Trappins via the GQDPVK epitope. TRAB2O shows strong reaction with Human native full-length Elafin/SKALP and a weaker reaction with fully processed Elafin/SKALP (C-terminal 57 aa). For detection of fully processed Elafin/SKALP (C-terminal 57 aa) we advise to use AM26266PU-N. The antibody is cross reactive with Trappin family members of other species with GQDPVK epitope.
Formulation	PBS State: Purified State: Liquid 0.2 µm filtered Ig fraction Stabilizer: 0.1% BSA Preservative: 0.02% Sodium Azide
Concentration	lot specific
Purification	Protein G Chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C.
Gene Name	peptidase inhibitor 3
Database Link	Entrez Gene 5266 Human UniProt ID P19957
Background	Elafin is an epithelial proteinase inhibitor also known under various other names such as Skin-derived Anti leukoproteinase (SKALP) and Elastase-Specific Inhibitor (ESI). Elafin belongs to the Trappin gene family and was given the systematic name Trappin-2. The Trappin family is defined by a N-terminal transglutaminase substrate domain and a C-terminal four disulphide core. Trappins have been suggested to play a role in the regulation of inflammation and in protection against tissue damage in stratified epithelia. Elafin is an inhibitor of leukocyte elastase and proteinase-3 and is a substrate for transglutaminases. The protein is constitutively expressed in various epithelia including hair follicles, oesophagus, vagina and oral cavity. Elafin is not present in normal human skin but is strongly induced during inflammation as in psoriasis and wound healing. Antibodies to Elafin can be used to evaluate the effects of treatment of psoriasis since its expression is significantly correlated with clinical scores. Antibodies to Elafin have also been succesfully used to study differentiation in squamous cell carcinoma of the head-and-neck region, oesophagus and skin. It is also shown that Elafin possesses antimicrobial activity against gram-positive and gram-negative bacteria.
Synonyms	Elastase-specific inhibitor, ESI, Peptidase inhibitor 3, PI-3, SKALP, WAP3, WFDC14
Reference Data

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