IL1 Receptor II (IL1R2) Mouse Monoclonal Antibody [Clone ID: 8.5]

Specifications

Product Data
Clone Name	8.5
Applications	ELISA, WB
Recommend Dilution	Flow cytometry: The typical starting working dilution is 1:50. Immunoassay. Western blot: The typical starting working dilution is 1:50.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Specificity	The antibody reacts specificly with IL-1RII.
Formulation	PBS State: Purified State: Liquid 0.2 µm filtered Ig fraction Stabilizer: 0.1% bovine serum albumin Preservative: containing 0.02% sodium azide
Concentration	lot specific
Purification	Protein G
Conjugation	Unconjugated
Storage Condition	Store at 2 - 8 °C.
Gene Name	interleukin 1 receptor type 2
Database Link	Entrez Gene 7850 Human UniProt ID P27930
Background	The IL-1 system includes two agonists (IL-1alpha and IL-1beta), converting enzymes, antagonists, two receptors (IL-1RI and IL-1RII) and the IL-1 receptor accessory protein. The IL-1RII is part of the antagonistic IL-1 mechanism. It is also known as decoy receptor and is a non signaling molecule which functions by capturing IL-1 and preventing it from interacting with the signalling IL-1RI. The decoy IL-1RII can after binding to IL-1 also recruit the IL-1 receptor accessory protein and thus inhibit by coreceptor competition. Further a soluble form of IL-1RII exists which is shed, a process in which matrix metalloproteases have been found to play a role, by various cells including monocytes, polymorphonuclear cells, B cells and fibroblasts.
Synonyms	Interleukin-1 receptor type II, IL-1R-2, IL-1R-beta, CDw121b, IL1RB
Reference Data

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