LBP Mouse Monoclonal Antibody [Clone ID: 6G3]

CAT#: AM26277PU-N

LBP mouse monoclonal antibody, clone 6G3, Purified



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CNY 7,031.00


货期*
5周

规格
    • 100 ug

Product images

Specifications

Product Data
Clone Name 6G3
Applications ELISA, FN, IP
Recommend Dilution Functional assays.
ELISA both as coating and detector.
Immunoprecipitation.
Not useful for immunohistology neither for Western blot.
Reactivity Bovine, Canine, Goat, Human, Monkey, Porcine, Rabbit, Rat, Sheep
Host Mouse
Clonality Monoclonal
Specificity The monoclonal antibody 6G3 reacts highly specific with human natural and recombinant LBP. The antibody binds to LBP-LPS complexes whereas it inhibits the interaction of this complex with CD14.
Formulation PBS
State: Purified
State: Liquid 0.2 µm filtered Ig fraction
Stabilizer: 0.1% bovine serum albumin
Preservative: 0.02% sodium azide
Concentration lot specific
Purification Protein G
Conjugation Unconjugated
Storage Condition

Store at 2 - 8 °C.

Gene Name lipopolysaccharide binding protein
Background LPS binding protein (LBP) is an approximately 60 kDa acute phase protein that is produced by hepatocytes. This protein strongly binds to LPS and has been shown to play an important role in the handling of LPS by the host. A number of functions of LBP have been reported. First, LBP transfers LPS to the LPS receptor CD14 on mononuclear phagocytes, leading to an 100-1,000 fold increased sensitivity of the cells to LPS. Furthermore, LBP can enhance the response of CD14 negative cells by acceleration of LPS binding to soluble CD14, a complex that stimulates these cells. Next, LBP transfers LPS into High Density Lipoprotein (HDL), which effectively neutralizes its biological potency. LBP was demonstrated to protect mice from septic shock caused by LPS or gram negative bacteria.
Synonyms Lipopolysaccharide-binding protein
Reference Data
Protein Families Druggable Genome, Secreted Protein
Protein Pathways Toll-like receptor signaling pathway
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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