Polymyxin B Mouse Monoclonal Antibody [Clone ID: 45]
CAT#: AM26366LE-N
Polymyxin B mouse monoclonal antibody, clone 45, Low Endotoxin
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CNY 7,031.00
货期*
5周
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Specifications
Product Data | |
Clone Name | 45 |
Applications | ELISA, WB |
Recommend Dilution | Immunoassays. Western blot: The typical starting working dilution is 1/10. |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Specificity | The monoclonal antibody 45 reacts with Polymyxin B. It enables the possibilities to study quantitatively the interaction of PMB and LPS. |
Formulation | State: Low Endotoxin State: Liquid Culture Medium with a Low endotoxin Level Preservative: 0.02% Sodium Azide |
Concentration | lot specific |
Conjugation | Unconjugated |
Storage Condition | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. |
Background | The peptide antibiotic Polymyxin B (PMB) binds to bacterial endotoxin (lipopolysaccharide, LPS). The interaction of PMB with LPS involves ionic forces between amino groups in PMB and negatively charged phosphate and carboxyl groups in the lipid A-Kdo region. PMB has relevance for endotoxin research in at least two ways: first, PMB reacts with LPS of many species regardless of varied serospecificity, and thus it can be used as a general probe for measuring or detecting LPS or lipid A. Second, binding of PMB to LPS may result in neutralization of the detrimental effects of LPS either in vitro or in vivo. |
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