alpha 1 Antitrypsin (SERPINA1) Mouse Monoclonal Antibody [Clone ID: 9F2]

Specifications

Product Data
Clone Name	9F2
Applications	ELISA, WB
Recommend Dilution	Western blot: Detect α1-antitrypsin (AAT) using mAb 9F2 at 1:5000 dilution (0.2 μg/mL). ELISA.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human plasma derived α1-antitrypsin
Specificity	This antibody with Human Alpha-1-antitrypsin.
Formulation	0.01M PBS pH7.2 State: Aff - Purified State: Lyophilized Ig fraction
Reconstitution Method	Double distillated water is recommended to adjust the final concentration to 1.00 mg/ml.
Purification	Protein G affinity purified
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Gene Name	serpin family A member 1
Database Link	Entrez Gene 5265 Human UniProt ID P01009
Background	Alpha-1-antitrypsin (AAT) is a protective protease inhibitor. It inhibits elastase released by neutrolphils during inflammatory reaction and irreversibly inactivates trypsin secreted in duodenum and elsewhere. α1-antitrypsin normally presents in plasma at 1.5-3.5 mg/mL, but increases in acute phase reaction, malignancies, pregnancy and trauma. Severe hereditary a1-antitrypsin deficiency can result in damages to alveoli, chronic obstructive pulmonary disease (COPD), and liver diseases such as jaundice and cirrhosis. The protein is also found in the neurofibrillary tangles and senile plaques in the brain lesions of Alzheimer’s disease, and has been suggested to contribute to the pathology of Alzheimer’s disease.
Synonyms	SERPINA1, AAT
Reference Data

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