alpha 1 Antichymotrypsin (SERPINA3) Mouse Monoclonal Antibody [Clone ID: B7B10]

Specifications

Product Data
Clone Name	B7B10
Applications	WB
Recommend Dilution	Western blot: Detect α1-ACT using antibody B7B10 at 1:5000 (0.2μg/mL) dilution.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human serum derived a1- antichymotrypsin
Specificity	This antibody recognizes native a1- antichymotrypsin.
Formulation	0.01M PBS pH7.2 State: Aff - Purified State: Lyophilized Ig fraction
Reconstitution Method	Double distillated water is recommended to reconstitute the antibody.
Purification	Protein G affinity purified
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month  or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Gene Name	serpin family A member 3
Database Link	Entrez Gene 12 Human UniProt ID P01011
Background	Chymotrypsins, such as Chymotrypsin C (also known as pancreatic Chymotrypsin or Chymotrypsin), are digestive enzymes that can perform proteolysis by cleaving peptides at the carboxyl side of tyrosine, tryptophan and phenylalanine, although over time they can also hydrolyze other amide bonds, especially those with leucine-donated carboxyls. Chymotrypsins cleave peptide bonds by attacking the un-reactive carbonyl group with a powerful nucleophile, the Serine 195 residue located in the active site of the enzyme, which momentarily becomes covalently bonded to the substrate to form an intermediate. Chymotrypsin C is synthesized in the pancreas by protein biosynthesis as a precursor called chymotrypsinogen that is enzymatically inactive, but becomes active as a three polypeptide molecule that is interconnected by disulfide bonds.
Synonyms	SERPINA3, AACT, GIG24, GIG25
Reference Data

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