DEP1 (PTPRJ) (1-444) Mouse Monoclonal Antibody [Clone ID: MEM-CD148/05]

Specifications

Product Data
Clone Name	MEM-CD148/05
Applications	FC
Recommend Dilution	Flow Cytometry.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human recombinant CD148 (amino acids 1-444)
Specificity	The antibody recognizes CD148, a highly glycosylated up to 250 kDa receptor-like protein tyrosin phosphatase expressed mainly in lymphocytes, myeloid cells and epithelial cells.
Formulation	PBS, approx. pH 7.4 State: Aff - Purified State: Liquid purified fraction  (> 95% pure by SDS-PAGE) Preservative: 15 mM Sodium Azide
Concentration	lot specific
Purification	Affinity Chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	protein tyrosine phosphatase, receptor type J
Database Link	Entrez Gene 5795 Human UniProt ID Q12913
Background	CD148 (also known as HPTP-eta or DEP-1) is a transmembrane protein tyrosin phosphatase containing eight fibronectin type III extracellular domains. This protein is known to inhibit transduction of mitogenic signals in non-hematopoietic cells (fibroblasts, epithelial cells), and signal transduction downstream of T cell receptor, however, it also augments immunoreceptor signaling in B cells and macrophages via dephosphorylating C-terminal tyrosine of Src-family tyrosine kinases. CD148 expression increases after in vitro activation of peripheral blood leucocytes. It can be also used as marker of the most mature human thymocytes, and leukemic cells corresponding to this stadium of thymocyte differentiation. In contrast, in mice the CD148 expression sharply drops through the double positive stage to the single positive thymocytes.
Synonyms	DEP1, DEP-1, HPTP eta, R-PTP-eta, Protein-tyrosine phosphatase eta, R-PTP-J
Reference Data

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