HLA Class II DR Mouse Monoclonal Antibody [Clone ID: L243]
CAT#: AM26708PU-N
HLA Class II DR mouse monoclonal antibody, clone L243, Purified
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CNY 3,280.00
货期*
5周
规格
Cited in 8 publications. |
Specifications
Product Data | |
Clone Name | L243 |
Applications | FC, FN, IF, IHC, IP, WB |
Recommend Dilution | Flow Cytometry. Immunoprecipitation. Western blot. Immunohistochemistry on Paraffin Sections. Immunohistochemistry on Frozen Sections. Immunocytochemistry. Functional Application: blocking. |
Reactivity | Canine, Human, Primate |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Human B lymphocytes |
Specificity | This antibody recognizes specifically HLA-DR molecules, both peptide-loaded and empty. |
Formulation | PBS, pH~7.4 State: Purified State: Liquid purified IgG fraction (> 95% by SDS-PAGE) Preservative: 15 mM Sodium Azide |
Concentration | lot specific |
Purification | Affinity Chromatography on Protein A |
Conjugation | Unconjugated |
Storage Condition | Store undiluted at 2-8°C. DO NOT FREEZE! |
Background | HLA-DR, a member of MHC class II glycoproteins, that bind intracellularly processed peptides and present them to the Th cells, is composed of 36 kDa alpha chain and 27 kDa beta chain, both anchored in the plasma membrane. Together with other MHC II molecules HLA-DR plays a central role in the immune system. It is expressed on antigen-presenting cells (dendritic cells, B lymphocytes, monocytes, macrophages). |
Synonyms | HLA-DR, HLA class II histocompatibility antigen DR, MHC class II antigen DR |
Reference Data |
Citations (8)
The use of this Antibodies has been cited in the following citations: |
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MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation
,De Gassart A, Camosseto V, Thibodeau J, Ceppi M, Catalan N, Pierre P, Gatti E,
Proc. Natl. Acad. Sci. U.S.A.
,PubMed ID 18305173
|
Normal human kidney HLA-DR-expressing renal microvascular endothelial cells: characterization, isolation, and regulation of MHC class II expression
,Muczynski KA, Ekle DM, Coder DM, Anderson SK,
J. Am. Soc. Nephrol.
,PubMed ID 12707403
|
Zwitterionic polysaccharides stimulate T cells by MHC class II-dependent interactions
,Kalka-Moll WM, Tzianabos AO, Bryant PW, Niemeyer M, Ploegh HL, Kasper DL,
J. Immunol.
,PubMed ID 12444118
|
Lipid raft-dependent and -independent signaling through HLA-DR molecules
,Bouillon M, El Fakhry Y, Girouard J, Khalil H, Thibodeau J, Mourad W,
J. Biol. Chem.
,PubMed ID 12499388
|
Monoclonal antibodies directed to CD20 and HLA-DR can elicit homotypic adhesion followed by lysosome-mediated cell death in human lymphoma and leukemia cells
,Ivanov A, Beers SA, Walshe CA, Honeychurch J, Alduaij W, Cox KL, Potter KN, Murray S, Chan CH, Klymenko T, Erenpreisa J, Glennie MJ, Illidge TM, Cragg MS,
J. Clin. Invest.
,PubMed ID 19620786
|
Comment on "MHC class II expression identifies functionally distinct human regulatory T cells"
,Swiatek-de Lange M, Rist W, Stahl HF, Weith A, Lenter MC,
J. Immunol.
,PubMed ID 18322165
|
A novel virus capture assay reveals a differential acquisition of host HLA-DR by clinical isolates of human immunodeficiency virus type 1 expanded in primary human cells depending on the nature of producing cells and the donor source
,Cantin R, Martin G, Tremblay MJ,
J. Gen. Virol.
,PubMed ID 11714974
|
Triggering of HLA-DR antigens differentially modulates tumor necrosis factor alpha release by B cells at distinct stage of maturation
,Coral S, Pucillo C, Leonardi A, Fonsatti E, Altomonte M, Maio M,
Cell Growth Differ.
,PubMed ID 9149909
|
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