C5R1 (C5AR1) Mouse Monoclonal Antibody [Clone ID: 3C6]

Specifications

Product Data
Clone Name	3C6
Applications	IHC
Recommend Dilution	Immunohistochemistry on Paraffin Sections: 4 µg/ml (1/100). Pretreatment with Proteinase K is required. Positive Control: Human placenta.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	DNA vaccine
Specificity	This antibody detects Human C5aR (CD88).  The specificity of the antibody was verified by flow cytometry with cells expressing the recombinant protein. The epitope has not been further characterized.
Formulation	Phosphate buffered saline pH 7.2 (PBS) State: Purified State: Lyophilized purified Ig fraction Stabilizer: 5 mg/ml BSA Preservative: 0.1% Kathon
Reconstitution Method	Restore by adding 0.5 ml distilled water.
Purification	Affinity Chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C for 6 month or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Gene Name	complement component 5a receptor 1
Database Link	Entrez Gene 728 Human UniProt ID P21730
Background	C5aR is a 350 amino acid, 45kDa member of the G - protein coupled receptor 1 family (GPCR) that interacts with C5a with very high binding affinity and, to a lesser extent, with C5adesArg. It is a seven - membrane - spanning receptor found on neutrophils (PMN) and macrophages, and on a variety of other cell types such as endothelial cells, alveolar epithelial cells and Kupffer cells. C5aR is biochemically and apparently also functionally different from the other recept or for C5a, C5L2.
Synonyms	C5a-R, C5aR, C5AR1, Complement Component 5a Receptor 1
Reference Data

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