CX3CR1 Mouse Monoclonal Antibody [Clone ID: 1G4]

Specifications

Product Data
Clone Name	1G4
Applications	IHC
Recommend Dilution	Immunohistochemistry on Paraffin Sections: 2 µg/ml (1/100), pretreatment with proteinase K required. Suggested Positive Control: Human brain cortex.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	DNA vaccine
Specificity	This antibody detetcs CX3C Receptor 1. The specificity of the antibody was verified by flow cytometry with cells expressing the recombinant protein. The epitope has not been further characterized.
Formulation	Phosphate buffered saline pH 7.2 (PBS) State: Purified State: Lyophilized purified IgG fraction from Serum-Free Cell Culture Supernatant Stabilizer: 5 mg/ml BSA Preservative: 0.1% Kathon
Reconstitution Method	Restore by adding 0.5 ml distilled water.
Concentration	0.2 mg/ml (after reconstitution)
Purification	Affinity Chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Gene Name	C-X3-C motif chemokine receptor 1
Database Link	Entrez Gene 1524 Human UniProt ID P49238
Background	G-protein coupled receptor 1 3 (GPR13) is a 355 amino acid protein that belongs to the G - protein coupled receptor 1 family. Biologically, the fractalkine (CX3CL1) to fractalkine receptor (CX3CR1) interactions play an important role in macrophage recruitment to target organs such as the brain, the intestine, the liver or the lungs. Accordingly, expression of the CX3CR1 has been described in inflammation - and tumor - associated macrophages, intestinal lamina propia macrophages, and B cells. Also, CX3CR1 mediates adhesive and migratory functions and acts as a coreceptor with CD4 for HIV - 1 virus gp160 envelope protein.
Synonyms	CX3C chemokine receptor 1, C-X3-C CKR-1,CMKBRL1, CMK-BRL-1
Reference Data

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