Msr1 Rat Monoclonal Antibody [Clone ID: 2F8]

Specifications

Product Data
Clone Name	2F8
Applications	IHC
Recommend Dilution	Immunohistochemistry on frozen sections: 10 µg/ml (1:100). Does not react on routinely processed paraffin sections. Sugeested positive control: Mouse spleen.
Reactivity	Mouse
Host	Rat
Clonality	Monoclonal
Immunogen	Raw 264 cell line
Specificity	This antibody recognises the murine scavenger receptor types I and II. It inhibits the uptake of acetylated low-density lipoproteins and also inhibits divalent cation independent adhesion. The molecule recognised is expressed by tissue macrophages and functions both as an endocytic receptor for lipoproteins and as an adhesion receptor for macrophages binding to ligand rich tissues, e.g. atherosclerotic lesions. Monoclonal antibody 2F8 recognizes an epitope within the α-helical coiled-coil domain of SR-A in all mouse strain s tested, with the exception of C57BL/6. One amino - acid change (L168S), due to polymorphism, results in the loss of reactivity of antibody 2F8.
Formulation	Phosphate buffered saline pH 7.4 (PBS) State: Purified State: Liquid affinity purified Ig fraction Preservative: 0.09 % Sodium azide
Concentration	1.0 mg/ml
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C.
Gene Name	macrophage scavenger receptor 1
Database Link	Entrez Gene 20288 Mouse UniProt ID P30204
Synonyms	MSR1, SCARA1
Reference Data

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