Claudin 6 (CLDN6) Rat Monoclonal Antibody [Clone ID: YD-9H8]

CAT#: AM26752PU-N

Claudin 6 (CLDN6) rat monoclonal antibody, clone YD-9H8, Purified



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CNY 5,660.00


货期*
5周

规格
    • 100 ug

Product images

Specifications

Product Data
Clone Name YD-9H8
Applications ELISA, FC, WB
Recommend Dilution Flow cytometry: 1.2 µg/106 cells.
ELISA: 1/200-1/400.
CELISA: 1/200-1/400.
Cell based ELISA with intakt, transiently transfected cells: 1/200-1/400.
Reactivity Human
Host Rat
Clonality Monoclonal
Immunogen cDNA encoding Human Claudin 9.
Selection: based on recognition of the complete native protein expressed on transfected mammalian cells.
Specificity This antibody detects Human Claudin-6 and Claudin-9.
Formulation PBS, pH 7.2
State: Purified
State: Liquid purified Ig fraction
Preservative: None
Concentration lot specific
Purification Protein G Chromatography
Conjugation Unconjugated
Storage Condition Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Gene Name claudin 6
Background Claudin 6 and Claudin 9 belong to the claudin family which constitutes a large group of four - transmembrane domain proteins (1) . Claudins are integral tight junction proteins that are responsible for maintaining the integrity of epithelial cell architecture, the control of parace llular transport and cell polarity. The expression pattern of claudins is tissue specific, most tissues express multiple claudins, which can interact in both homotypic and heterotypic fashion to form the tight junction strands (2) . Several claudin proteins have been shown to be abnormally expressed in cancers. The differential expression of these proteins between tumour and normal cells, in addition to their membrane localisation, makes them prime candidates for cancer therapy (2). Members of the claudin fa mily, including Claudin 6 and 9 are expressed in the liver and play a critical role in Hepatitis C Infection. They function as coreceptors in HCV entry and assume a role in HCV dissemination, replication and pathogenesis (3).
Synonyms CLDN6, PRO1488, Skullin, Skullin 2, UNQ757, CLDN9
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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