CD1B Mouse Monoclonal Antibody [Clone ID: SN13]

Specifications

Product Data
Clone Name	SN13
Applications	IHC, IP
Recommend Dilution	Flow cytometry. Immunoprecipitation. Immunohistochemistry on frozen sections. Immunohistochemistry on paraffin sections.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	A cell membrane antigen preparation that was isolated from normal human thymocytes
Specificity	This antibody recognizes CD1b, a 44 kDa type I glycoprotein associated with beta2-microglobulin. It is expressed on dendritic cells, Langerhans cells, thymocytes, and T acute lymphoblastic leukemia cells.
Formulation	Phosphate buffered saline (PBS) State: Purified State: Liquid Ig fraction Preservative: 15 mM sodium azide, approx. pH 7.4
Concentration	lot specific
Purification	Protein-A affinity chromatography (> 95% pure by SDS-PAGE)
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	CD1b molecule
Database Link	Entrez Gene 910 Human UniProt ID P29016
Background	CD1b (also known as R1) together with CD1a and c, belongs to group 1 of CD1 antigens. These non-classical MHC-like glycoproteins serve as antigen-presenting molecules for a subset of T cells that responds to specific lipids and glycolipids found in the cell walls of bacterial pathogens or self-glycolipid antigens such as gangliosides, and they have also roles in antiviral immunity. The trafficking routes of the particular CD1 types differ and correspond to their ability to bind and present different groups of antigens. Besides non-peptide glycolipid antigen presentation to CD1-restricted T cells, CD1b has been implicated in thymocyte development.
Synonyms	CD1; CD1A; MGC125990; MGC125991; R1
Reference Data

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