LRRC32 Mouse Monoclonal Antibody [Clone ID: GARP5]

Specifications

Product Data
Clone Name	GARP5
Applications	WB
Recommend Dilution	Western blot: 1-2 µg/ml positive control: human thrombocytes, reducing conditions
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified human sGARP protein
Specificity	This antibody recognizes GARP / LRRC32, an approximately 80 kDa glycoprotein expressed e.g. on the surface of megakaryocytes, platelets and activated Treg cells.
Formulation	Phosphate buffered saline (PBS) State: Purified State: Liquid Ig fraction Preservative: 15 mM sodium azide, approx. pH 7.4
Concentration	lot specific
Purification	Protein-A affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	leucine rich repeat containing 32
Database Link	Entrez Gene 2615 Human UniProt ID Q14392
Background	GARP (glycoprotein A repetitions predominant protein), also known as Garpin or LRRC32 (leucin-rich repeat containing protein 32) is an approximately 80 kDa transmembrane glycoprotein detected on the surface of megakaryocytes, platelets, and activated Treg cells. It binds to the latency-associated peptide (LAP) domain of pro-TGF beta and regulates its storage and activation. The expression of GARP on Treg cells seems to be necessary for their suppressive functions.
Synonyms	Garpin, D11S833E
Reference Data

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