ZNFN1A2 (IKZF2) (51-107) Hamster Monoclonal Antibody [Clone ID: 22F6]

Specifications

Product Data
Clone Name	22F6
Applications	FC
Recommend Dilution	Flow cytometry: Intracellular staining.
Reactivity	Human, Mouse
Host	Hamster
Clonality	Monoclonal
Immunogen	Peptide coresponding to the amino acids 51-107 of Helios
Specificity	This antibody recognizes Helios, a transcription factor expressed in some hematopoietic stem cells, and at high levels in thymic-derived regulatory T cells.
Formulation	Phosphate buffered saline (PBS) State: Purified State: Liquid Ig fraction Preservative: 15 mM sodium azide, approx. pH 7.4
Concentration	lot specific
Purification	Protein-A affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	IKAROS family zinc finger 2
Database Link	Entrez Gene 22807 Human UniProt ID Q9UKS7
Background	Helios, also known as IKZF2 (Ikaros family zinc finger protein 2) is a hematopoietic-specific transcription factor involved in the regulation of lymphocyte development, together with other members of this family, such as Aiolos and Ikaros. Helios forms homo- and heterodimers with these proteins and is thought to function predominantly in early hematopoietic development. Expression of Helios, Aiolos and Ikaros is restricted to cells of the hematopoietic system, whereas other family members, Eos and Pegassus, are more widely expressed. Helios is expressed at early stages of thymocyte development. In mature T cells, Helios has been strongly associated with Treg cells.
Synonyms	helios; MGC34330; OTTHUMP00000163964; ZNF1A2; ZNFN1A2
Reference Data

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