VEGF Receptor 2 (KDR) (2nd Extracell. Dom.) Rat Monoclonal Antibody [Clone ID: BEP-5A1]
CAT#: AM26789PU-N
VEGF Receptor 2 (KDR) (2nd Extracell. Dom.) rat monoclonal antibody, clone BEP-5A1, Purified
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CNY 5,660.00
货期*
5周
规格
Specifications
Product Data | |
Clone Name | BEP-5A1 |
Applications | ELISA, FC |
Recommend Dilution | Flow Cytometry: 1.2 μg/106 cells. ELISA: 1/200-1/400. Cell-based ELISA: 1/200-1/400. |
Reactivity | Human, Porcine |
Host | Rat |
Clonality | Monoclonal |
Immunogen | Complete extracellular domain of human VEGFR-2 which has been shown to be specific for the native target molecule and its counterpart in pigs using FACscan analyses on viable, transiently-transfected human BOSC23 cells (see Fig. 1). Selection: based on recognition of the complete native protein expressed on transfected mammalian cells. |
Specificity | This antibody detects VEGFR2 at the second extracellular immunoglobulin-like domain. |
Formulation | Phosphate buffered saline, pH 7.2 State: Purified State: Liquid purified Ig fraction |
Concentration | lot specific |
Purification | Protein G Chromatography |
Conjugation | Unconjugated |
Storage Condition | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Gene Name | kinase insert domain receptor |
Database Link | |
Background | The vascular endothelial growth factor receptor-2 (VEGFR-2) plays an important role in the control of angiogenesis. This molecule is expressed on the surface of circulating endothelial stem cells as well as on adult vascular endothelial cells and other cell types (1). It is a 200-kDa type I transmembrane protein, consisting of a 19 amino acid leader peptide, a 744 amino acid extracellular domain made up of 7 immunoglobulin-like domains, a 24 amino acid transmembrane region and a 568 amino acid cytoplasmic domain. Interactions with VEGF ligands will stimulate angiogenesis, required in wound healing but also misused by tumours to promote their vascularization (2). |
Synonyms | VEGFR2, FLK1, KDR, VEGF Receptor 2 |
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