CD95 (FAS) Mouse Monoclonal Antibody [Clone ID: EOS9.1]

Specifications

Product Data
Clone Name	EOS9.1
Applications	FC, FN
Recommend Dilution	Flow cytometry. Functional application (in vitro induction of apoptosis).
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	P815 cells transfected with human CD95
Specificity	This antibody recognizes CD95 (Fas/APO-1), a 46 kDa glycoprotein of the tumour necrosis factor/nerve growth factor (TNF/NGF) receptor superfamily, expressed on a variety of normal and neoplastic cells.
Formulation	Tris buffered saline (TBS) State: Purified State: Liquid purified Ig fraction  (> 95% pure by SDS-PAGE) Preservative: 15 mM sodium azide, approx. pH 8.0
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	Fas cell surface death receptor
Database Link	Entrez Gene 355 Human UniProt ID P25445
Background	CD95 (Fas, APO-1), a 46 kDa transmembrane glycoprotein, is a cell death receptor of the TNFR superfamily. Stimulation of CD95 results in aggregation of its intracellular death domains, formation of the death-inducing signaling complex (DISC) and activation of caspases. In type I cells caspase 3 is activated by high amounts of caspase 8 generated at the DISC, in type II cells low concentration of caspase 8 activates pathway leading to the release of cytochrome c from mitochondria and activation of caspase 3 by cytochom c. Besides its roles in induction of apoptosis, Fas also triggers pro-inflammatory cytokine responses.
Synonyms	FASLG receptor, Apo-1 antigen, APT1, FAS1, TNFRSF6
Reference Data

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