KIR2DL1 Mouse Monoclonal Antibody [Clone ID: HP-MA4]

Specifications

Product Data
Clone Name	HP-MA4
Applications	FC, IP
Recommend Dilution	Flow cytometry. Immunoprecipitation.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human NK cell line LB2
Specificity	This antibody recognizes CD158 isoforms KIR2DL1 (CD158a), KIR2DS5 (CD158g), KIR2DS1 (CD158h), and KIRDS3. It does not recognize the isoforms CD158b1,d,f,i,j.
Formulation	Phosphate buffered saline (PBS) State: Purified State: Liquid Ig fraction Preservative: 15 mM sodium azide, approx. pH 7.4
Concentration	lot specific
Purification	Protein-A affinity chromatography (> 95% pure by SDS-PAGE)
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1
Database Link	Entrez Gene 3802 Human UniProt ID P43626
Background	Killer cell immunoglobulin-like receptors (KIRs) are polymorphic transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. They are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain (such as CD158a / KIR2DL1) transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain (such as CD158g / KIR2DS5, CD158h / KIR2DS1, or KIR2DS3) lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for CD158 isoforms are subsets of MHC class I molecules.
Synonyms	NKAT1, KIR2DL1, KIR2DS5, NKAT9, KIR2DS1
Reference Data

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