DR3 (TNFRSF25) Mouse Monoclonal Antibody [Clone ID: JD3]
CAT#: AM26797PU-N
DR3 (TNFRSF25) mouse monoclonal antibody, clone JD3, Purified
Conjugation: PE
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AM26797PU-N is a replacement of TA320498.
CNY 3,140.00
货期*
5周
规格
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Specifications
Product Data | |
Clone Name | JD3 |
Applications | FC |
Recommend Dilution | Flow cytometry. |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Human DR3-Ig fusion protein |
Specificity | This antibody recognizes DR3 (APO-3, TNFRSF12), a transmembrane protein of TNFR superfamily expressed mainly in lymphocyte-enriched tissues. |
Formulation | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 State: Purified State: Liquid Ig fraction |
Concentration | lot specific |
Purification | Protein-A affinity chromatography (> 95% pure by SDS-PAGE) |
Conjugation | Unconjugated |
Storage Condition | Store undiluted at 2-8°C. DO NOT FREEZE! |
Gene Name | tumor necrosis factor receptor superfamily member 25 |
Database Link | |
Background | DR3, also known as APO-3, TRAMP or TNFRSF12, is a death domain-containing receptor of TNFR family, which is expressed preferentially in peripheral blood leukocytes and in the lymphocyte-enriched tissues. Its expression has been shown to be especially up-regulated in activated T cells. DR3 participates e.g. in the removal of self-reactive T cells in the thymus. The ligand for DR3 is TL1A (TNF-like ligand 1A), which is expressed in a variety of cell types (induced by inflammatory stimuli), and can also be released as a soluble factor. The TL1A/DR3 axis has been shown to costimulate T cells to produce a wide variety of cytokines and leads to T cell differentiation towards Th1 and Th17 types. |
Synonyms | APO3, DDR3, TNFRSF12, WSL, WSL1, Apo-3, AIR, Death receptor 3, LARD, Protein WSL, Protein WSL-1 |
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