CD193 / CCR3 Mouse Monoclonal Antibody [Clone ID: 5E8]

Specifications

Product Data
Clone Name	5E8
Applications	FC
Recommend Dilution	Flow Cytometry analysis of human blood cells using 10 ?l reagent / 100 ?l of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Specificity	This antibody recognizes CD193 (chemokine receptor 3), an approximately 41 kDa protein expressed above all in eosinophils and basophils.
Formulation	Phosphate buffered saline (PBS) containing 15 mM sodium azide Label: APC State: Liquid purified Ig fraction Label: Conjugated with cross-linked Allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use.
Conjugation	APC
Storage Condition	Store the antibody undiluted at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Gene Name	C-C motif chemokine receptor 3
Database Link	Entrez Gene 1232 Human UniProt ID P51677
Background	CD193 / CCR3 is a G-protein coupled receptor for several chemokines, namely CCL11 (eotaxin), CCL26 (eotaxin-3), CCL7 (MCP-4), or CCL5 (RANTES). It is highly expressed on eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. CD193 is the key eosinophil chemokine receptor responsible for regulation of eosinophil migration and function. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1.
Synonyms	C-C chemokine receptor type 3, C-C CKR-3, CC-CKR-3, CCR-3, CKR3, CMKBR3
Reference Data

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