IL2 Receptor alpha (IL2RA) Mouse Monoclonal Antibody [Clone ID: B-B10]

Specifications

Product Data
Clone Name	B-B10
Applications	FC, FN
Recommend Dilution	Flow Cytometry. Functional Assay: Inhibits Mixed Lymphocyte Culture.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	PHA activated T cells. Hybridoma: Myeloma X63/AG.8653 x Balb/c spleen cells
Specificity	Recognises the Interleukin 2 Receptor a chain (IL-2 Ra), a 55 kDa protein. This antibody recognizes only membrane bound Human IL-2 Ra
Formulation	Phosphate-buffered saline without Carrier and preservatives. This prodcut is sterile-filtered through 0.22 µm and treated to remove Endotoxins. State: Azide Free State: Liquid purified IgG fraction.
Concentration	lot specific
Purification	Ion Exchange Chromatography.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Gene Name	interleukin 2 receptor subunit alpha
Database Link	Entrez Gene 3559 Human UniProt ID P01589
Background	IL-2R (T-cell growth factor receptor) consists of a chain of 55kDa (also known as Tac antigen or p55 or alpha chain) and a p75 or beta chain. IL-2RA is over-expressed on the surface of activated Tcells, HTLV-1 or -2 positive T-cell lines, and moderately expressed on activated B-cells, NK-cells, and macrophages. CD25 molecule alone appears to function as a low affinity receptor and associates wtih CD122 (IL-2R beta chain, p75) and CD132 (common gamma chain) to form the high affinity IL-2 receptor complex.
Synonyms	Interleukin-2 receptor alpha chain, IL-2 receptor alpha subunit, IL-2-RA, IL2-RA, p55, TAC antigen
Note	Kd: 0.4 nM
Reference Data
Protein Families	Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
Protein Pathways	Cytokine-cytokine receptor interaction, Endocytosis, Hematopoietic cell lineage, Jak-STAT signaling pathway

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