IL12A Mouse Monoclonal Antibody [Clone ID: B-T21]

Specifications

Product Data
Clone Name	B-T21
Applications	FC, FN
Recommend Dilution	Flow Cytometry (Intra-cytoplasmic). Functional Assay: Blocks IL-12 induced proliferation on PHA and IL-2 activated lymphocytes.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant Human IL-12.
Specificity	This antibody recognizes both natural and recombinant Human IL-12 p35 + p70
Formulation	Phosphate-buffered saline without Carrier and preservatives. This prodcut is sterile-filtered through 0.22 µm and treated to remove Endotoxins. State: Azide Free State: Liquid purified IgG fraction
Concentration	lot specific
Purification	Ion Exchange Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Gene Name	interleukin 12A
Database Link	Entrez Gene 3592 Human UniProt ID P29459
Background	Interleukin 12 (IL12) is an important cytokine produced by a variety of immune effector cells that leads to a type 1 helper T cell (Th1) response. IL12 also directs T cells to the skin via induction of cutaneous lymphocyte antigen (CLA) expression. Interleukin 12 is a heterodimeric cytokine (p70), composed of two covalently linked subunits, p35 and p40 and is secreted primarily by activated B cells.
Synonyms	IL-12A, IL-12 subunit p35, NKSF1, CLMF p35
Reference Data
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Allograft rejection, Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway, Type I diabetes mellitus

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