CD62P (SELP) Mouse Monoclonal Antibody [Clone ID: B-F46]

Specifications

Product Data
Clone Name	B-F46
Applications	FC
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant Human CD62P
Specificity	This antibody recognises CD62P, a 140 kD single chain type I transmembrane glycoprotein present in secretory alpha-granules in platelets, Weibel-Palade bodies in endothelial cells and megakaryocytes. Recognises soluble and membrane antigen.
Formulation	Phosphate-buffered saline. Sterile-filtered through 0.22 µm. Carrier and preservative free State: Azide Free State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Ion Exchange Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Gene Name	selectin P
Database Link	Entrez Gene 6403 Human UniProt ID P16109
Background	CD62P (P-selectin) is an adhesion glycoprotein that is expressed on platelets and endothelial cells upon their activation. Interaction between CD62P and its mucin-like ligand PSGL-1 (P-selectin glycoprotein ligand-1) expressed on the microvilli of most leukocytes supports leukocyte rolling along postkapillary venules at the earliest time of inflammation. Both CD62P and PSGL-1 are extended glycoproteins that form homodimers. CD62P dimerization is probably mediated through interactions of the transmembrane domains and stabilizes leukocyte tethering and rolling, probably by increasing rebinding within a bond cluster.
Synonyms	SELP, GMRP, GRMP, PADGEM, GMP-140, LECAM3
Reference Data
Protein Families	Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
Protein Pathways	Cell adhesion molecules (CAMs)

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