CD14 Mouse Monoclonal Antibody [Clone ID: B-A8]

Specifications

Product Data
Clone Name	B-A8
Applications	ELISA, FC, IHC
Recommend Dilution	Flow Cytometry: Use 10 µl to label 10e6 cells or 100 µl of whole blood. ELISA: This clone has been used as a Capture antibody in a Sandwich ELISA for analysis of Human CD14 in combination with clone MEM-18. Immunohistochemistry on Paraffin Sections: 1/200 Positive staining on human PML brain sections was mainly observed on monocytes in the lumenal side using this clone antibody.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Monocytes.
Specificity	Recognises the lipopolysaccharide receptor (LPS R), a 55 kDa protein.
Formulation	PBS containing 1% BSA as stabilizer and 0.09% Sodium Azide as preservative. State: Purified State: Liquid purified IgG fraction
Purification	Ion Exchange Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Gene Name	CD14 molecule
Database Link	Entrez Gene 929 Human UniProt ID P08571
Background	CD14 is a 55 kDa GPI-anchored glycoprotein, constitutively expressed on the surface of mature monocytes, macrophages, and neutrophils, where serves as a multifunctional lipopolysaccharide receptor; it is also released to the serum both as a secreted and enzymatically cleaved GPI-anchored form. CD14 binds lipopolysaccharide molecule in a reaction catalyzed by lipopolysaccharide-binding protein (LBP), an acute phase serum protein. The soluble sCD14 is able to discriminate slight structural differences between lipopolysaccharides and is important for neutralization of serum allochthonous lipopolysaccharides by reconstituted lipoprotein particles. CD14 affects allergic, inflammatory and infectious processes.
Synonyms	CD14
Reference Data
Protein Families	Adult stem cells, Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS, Transmembrane
Protein Pathways	Hematopoietic cell lineage, MAPK signaling pathway, Pathogenic Escherichia coli infection, Regulation of actin cytoskeleton, Toll-like receptor signaling pathway

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