BCL3 Hamster Monoclonal Antibody [Clone ID: Ham150-3.5]
CAT#: AM31856PU-N
BCL3 hamster monoclonal antibody, clone Ham150-3.5, Purified
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CNY 5,896.00
货期*
5周
规格
Specifications
Product Data | |
Clone Name | Ham150-3.5 |
Applications | ELISA, FC, WB |
Recommend Dilution | This Clone has been described to work in ELISA, Western Blot and Flow Cytometry. |
Reactivity | Human, Mouse |
Host | Hamster |
Clonality | Monoclonal |
Immunogen | Recombinant Bcl-3-6-histidine tag from Armenian Hamster. Fusion Partner: SP2/0 myeloma. |
Specificity | Recognizes B-cell Leukemia/lymphoma 3 (Bcl-3). |
Formulation | PBS containing 0.02% Sodium Azide as preservative State: Purified State: Liquid purified IgG fraction |
Concentration | lot specific |
Purification | Protein G Affinity Chromatography |
Conjugation | Unconjugated |
Storage Condition | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Gene Name | B-cell CLL/lymphoma 3 |
Database Link | |
Background | B cell Lymphoma 3 is a member of the IkB subfamily of inhibitors. This subfamily is part of the NF-kB transcription factor protein family and it is suggested that a balance in the concentration of various NF-kB family members regulates apoptosis and survival of activated T cells. Bcl-3 has been shown to have versatile functions such as cytoplasmic activation of p50 homodimers, translocation to the nucleus, and modulation of the transcriptional machinery in the nucleus. Bcl-3 activity often relies on several nuclear interacting proteins such as Tip60, Jab1, Bard1, and Pirin. The Mouse Bcl-3 coding region exhibits 80% homology with Human Bcl-3 which is associated with human B-cell chronic lymphocytic leukemias (CLLs). Bcl-3 is detected in various tissues such as spleen and other lymphoid organs. |
Synonyms | BCL3, BCL4, D19S37 |
Reference Data | |
Protein Families | Druggable Genome, Transcription Factors |
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