Laminin gamma 1 (LAMC1) Mouse Monoclonal Antibody [Clone ID: BC17]

Specifications

Product Data
Clone Name	BC17
Applications	ELISA, IHC, IP
Recommend Dilution	ELISA. Immunoprecipitation. Immunohistochemical on Frozen Sections. Does not work in Western blotting.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Pepsin-digested laminins from Human placenta. Hybridoma produced by fusion between myeloma cells and Balb/c spleen cells.
Specificity	The antibody recognizes the Mr 200,000 gamma-1-chain of Human reduced and Alkylated Laminin produced by various cultured cells, which produce Laminins complexed with it. The specificity of Mab BC17 has been confirmed by Immunoprecipitation and ELISA by using recombinant gamma-1- chain. The antibody only reacts with Human cells and tissues (further studies are going on).
Formulation	PBS State: Ig Fraction State: Liquid Ig fraction Stabilizer: 1.0% BSA Preservative: 0.09% Sodium Azide
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Gene Name	laminin subunit gamma 1
Database Link	Entrez Gene 3915 Human UniProt ID P11047
Background	Laminin, a major structural glycoprotein of the basement membranes, is an attachment and survival factor for epithelial cells and can also promote the growth of epithelial cells. Laminin plays an important role in both the structural organization of basement membranes and in the anchorage of cells. The monoclonal antibody, DG10 and BC17 against laminin chain ß1 and γ1, respectively can be widely applied in immunohistochemical studies as all basement membranes contain laminin trimers containing these chains. Antibodies to laminin chains are useful in basic biology studies as well as in pathological studies concerning, for instance, the integrity of the basement membranes in carcinomas.
Synonyms	LAMC1, LAMB2, Laminin subunit gamma-1, Laminin B2 chain
Reference Data

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