Scarb1 Mouse Monoclonal Antibody [Clone ID: 3D12]

Specifications

Product Data
Clone Name	3D12
Applications	IHC, Neutralize
Recommend Dilution	Western Blot. Flow Cytometry. Immunohistochemistry on Frozen Sections.   Neutralization of biological activity: in vitro dilutions have to be made according to the amounts of SR-BI to be inactivated.  Use 1/10 as starting working dilution.
Reactivity	Rat
Host	Mouse
Clonality	Monoclonal
Specificity	Monoclonal antibody 3D12 reacts with rat class B scavenger receptor type I (SR-BI).  Clone 3D12 blocks the biological activity of rat SR-BI. For example, it inhibits the ability of SR-BI to mediate the corporation of lipids of HDL by SR-BI expressing cells.
Formulation	PBS State: Liquid State: Liquid 0.2 µm filtered Stabilizer: 0.1% BSA Preservative: 0.02% Sodium Azide
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Gene Name	scavenger receptor class B, member 1
Database Link	Entrez Gene 25073 Rat UniProt ID P97943
Background	Scavenger receptors have been studied primarily for their ability to bind and internalize modified lipoproteins. They have been found in the development of atherosclerosis and other macrophage-associated functions. Scavenger receptors also function as pattern recognition receptors for a wide variety of pathogens. This finding indicates a potential role in host defense. SR-BI belongs together with CD36 to the class B scavenger receptor family. SR-BI is a multiligand membrane protein existing in various organs such as the liver and various cell types such as endothelial cells, macrophages, brain cells, Leydig cells and Sertoli cells. SR-BI has been found as a receptor for phospholipids, free and (lipo)protein-bound ApoE, lipid-bound ApoA-I, HDL, hypochlorite-modified LDL and more. In liver, the PDZK-1 (and possible other PDZ domains) of SR-BI has been found to be essential for cell surface expression and, hence, reverse cholesterol transport. In the brain, the presence of SR-BI seems to be involved in the uptake of oxidatively modified lipoproteins and beta-amyloid protein complexed with ApoE, suggesting SR-BI to be an important tool for studies on neurodegenerative disorders. In the testis, SR-BI is expressed in two somatic cell types: Leydig cells and Sertoli cells. SR-BI functions at least partly as a phosphatidyl serine receptor (PSR), enabling Sertoli cells to recognize and phagocytose apoptotic spermatogenic cells at all stages of differentiation.
Synonyms	SRB1, SR-BI, CLA1, CLA-1, CD36L1
Reference Data

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