EMA (MUC1) Mouse Monoclonal Antibody [Clone ID: VU-3D1]

Specifications

Product Data
Clone Name	VU-3D1
Applications	ELISA, IHC
Recommend Dilution	ELISA. Immunohistochemistry on frozen sections.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	A Balb/c mouse was immunized with live cells (10e7 cells/dose in PBS) of human breast cancer cell line ZR-75-1. Splenocytes were fused with SP2/0 mouse myeloma cells. Stability of the hybridomas was established by subcloning four times.
Specificity	VU-3D1 reacts with MUC1.
Formulation	PBS State: Purified State: Liquid purified Ig fraction Preservative: 0.02% sodium azide
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	mucin 1, cell surface associated
Database Link	Entrez Gene 4582 Human UniProt ID P15941
Background	MUC1 is a large transmembrane glycoprotein expressed on the ductal surface of normal glandular epithelia. The extracellular domain of MUC1 largely consists of a highly conserved, O-glycosylated 20 aminoacids tandem repeat which can occur 30-100 times per molecule depending on the length of the allele involved. In the vast majority of human carcinomas this protein is upregulated and poorly glycosylated and appears on the cell surface in a non-polarized fashion. The dominant epitope of mAb VU3D1 is the 8-mer SAPDTRPA of the MUC1 tandem repeat as established with “epitope fingerprinting”.
Synonyms	MUC-1, PEMT, Episialin, EMA, H23AG, PUM, DF3, CA 15-3
Reference Data

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