CD105 (ENG) Mouse Monoclonal Antibody [Clone ID: E9]
CAT#: AM32279PU-N
CD105 (ENG) mouse monoclonal antibody, clone E9, Purified
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CNY 8,475.00
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Specifications
Product Data | |
Clone Name | E9 |
Applications | ELISA, FN, IHC, IP, WB |
Recommend Dilution | Western Blot. Immunoassay. Flow Cytometry. Immunoprecipitation. Immunohistochemistry on frozen and paraffin sections. |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | HUVEC |
Specificity | The monoclonal antibody E9 reacts with Endoglin a 190 kDa homodimeric transmembrane glycoprotein composed of disulfide-linked subunits.
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Formulation | PBS State: Purified State: Liquid purified Ig fraction (0.2 µm filtered) Stabilizer: 0,1% BSA Preservative: 0.02% sodium azide |
Concentration | lot specific |
Conjugation | Unconjugated |
Storage Condition | Store the antibody undiluted at 2-8°C. |
Gene Name | endoglin |
Database Link | |
Background | The external domain binds TGF-beta1 and -beta3 isoforms with high affinity. Two different isoforms (L and S) of CD105 with capacity to bind TGF-beta have been characterized which differ in the amino acid composition of their cytoplasmic tails. Mutations in the gene encoding endoglin have been linked to the human disease hereditary hemorrhagic telangiectasia type 1 (HHT1) a vascular disorder characterized by localized vascular dysplasia and a tendency towards arteriovenous malformations. Mice expressing a single CD105 allele develop external signs of disease similar to human HHT1, supporting the haploinsufficiency |
Synonyms | ENG, END, HHT1, ORW, ORW1 |
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