CD51 (ITGAV) Mouse Monoclonal Antibody [Clone ID: NKI-M9 (former PAF2a)]

Specifications

Product Data
Clone Name	NKI-M9 (former PAF2a)
Applications	ELISA, FN, IF, IHC, IP
Recommend Dilution	ELISA. Functional Studies on Vitronectin Receptor on Human platelets. Flow Cytometry.  Immunohistochemsitry on Frozen Sections.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Cultured melanoma cells derived from a Human melanoma metastasis.
Specificity	The antibody is directed against the CD51 antigen, alpha chain of Vitronectin Receptor (VNR-alpha chain) which forms a complex with: CD61 antigen (GP IIIa or b3 chain); b5 Integrin and b1 Integrin. The platelet alpha-beta-3 complex functions as a Vitronectin Receptor and platelet adhesion to Vitronectin is inhibited by this monoclonal by NKI-M9 antibody.
Formulation	PBS State: Purified State: Liquid purified IgG fraction Preservative: 0.09% Sodium Azide
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	integrin subunit alpha V
Database Link	Entrez Gene 3685 Human UniProt ID P06756
Background	CD51 (Cluster of Differentiation 51), known as vitronectin receptor α chain, or integrin αV is a type I integral membrane glycoprotein. CD51 forms a heterodimer with integrin β1 (CD29), β3 (CD61), β5, β6, or β8. CD51 contains two disulfide-linked subunits of 125 kD and 24 kD. Many extracellular matrix proteins with RGD-motifs are CD51 ligands. In association with its β chains, CD51 binds vitronectin, von Willebrand factor, fibronectin, thrombospondin, osteopontin, fibrinogen, and laminin. CD51, as an adhesion molecule, plays important roles in leukocytes homing and rolling, mediates bone absorption and angiogenesis. CD51 is expressed on endothelial cells, fibroblasts, macrophages, platelets, osteoclasts, neuroblastoma, melanoma, and hepatoma cells.
Synonyms	Integrin alpha-V, MSK8, VNRA, Vitronectin receptor subunit alpha
Reference Data

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