CD15 Mouse Monoclonal Antibody [Clone ID: BRA4F1]
CAT#: AM32396PU-N
CD15 mouse monoclonal antibody, clone BRA4F1, Purified
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CNY 4,724.00
货期*
5周
规格
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Product Data | |
Clone Name | BRA4F1 |
Applications | ELISA, FC, IHC |
Recommend Dilution | ELISA. Flow Cytometry. Immunohistochemistry on Frozen Sections. Immunohistochemistry on Paraffin Sections. |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | A BALB/c mouse was immunized with K562 (an erythroid-myeloid leukemia cell line). Splenocytes were fused with mouse myeloma SP2.0-Ag14 cells. |
Specificity | This antibody specifically detects CD15. CD15 contains the pentasaccharide lacto-N-fucopentatose III and is particularly expressed on granulocytes and mature neutrophils and on a wide variety of tumor cells including myeloid leukemia, breast, colorectal, and lung cancer cells. The mAb BRA4F1 was clustered at the IV th International Workshop on Leucocyte Differentiation Antigens. |
Formulation | PBS State: Purified State: Liquid purified Ig fraction Preservative: 0.05% Sodium Azide |
Concentration | lot specific |
Conjugation | Unconjugated |
Storage Condition | Store the antibody undiluted at 2-8°C. |
Background | CD15 is a carbohydrate that is referred to as the Lewis X antigen, also known as alpha-(1,3)-fucosyltransferase 4, which is expressed on a variety of glycolipids and glycoproteins found on the cell surface of neutrophils, monocytes, eosinophils and non-hematopoietic tissues including embryonic tissues. CD15 is reported to function as an adhesion molecule and is involved in chemotaxis and phagocytosis. Expression of CD15 is also associated with a wide variety of tumour cells including some adenocarcinomas and certain types of myeloid and lymphoid leukaemias. Reed-Sternberg cells, found in cases of Hodgkins Lymphoma, also express CD15 and antibodies recognising the CD15 antigen are often used to help differentiate between Hodgkins and non-Hodgkins lymphoma. |
Synonyms | Lewis X, X-Hapten, Lacto-N-Fucopentaose III, Stage-Specific Embryonic Antigen, SSEA1 |
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