CD57 / HNK1 Mouse Monoclonal Antibody [Clone ID: 6-13-19-1]

Specifications

Product Data
Clone Name	6-13-19-1
Applications	IF, IHC, MC
Recommend Dilution	Microcytotoxicity. Immunofluorescence.  Recommended Dilutions: Use 1/5 dilution in PBS containing 1% BSA and 0.02% Sodium Azide.  Positive Control: Peripheral blood lymphocytes.  Immunohistochemistry on Paraffin Sections.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Jurkat T-cell line
Specificity	The antibody clone 6-13-19-1 reacts with a 110 kD antigen present on the peripheral blood lymphocyte subset (primarily large granular lymphocytes) identified by the HNK-1 monoclonal antibody. It recognizes part of the Natural Killer cell population. CD57 is furthermore present on cells in neuroectodermal tissue.
Formulation	State: Liquid
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Background	Over 100 cell surface markers have been identified through the use of monoclonal antibodies. Many of these markers have proven useful in identifying a specific subpopulation of cells within a mixed colony. Accordingly, these molecules have been assigned a “cluster of differentiation” (CD) designation. T lymphocytes displaying the natural killer (NK) cell marker CD57 (also designated Leu7) on their cell surface are distinguishable from other T cell subsets by their granular lymphocyte morphology and their clonal expansion in patients with AIDS and in recipients of bone marrow transplantation. CD57+ cells have also been shown to localize to sites of certain tumors and large numbers of these cells are detected in the synovial fluid from patients suffering from rheumatoid arthritis.
Synonyms	HNK-1, LEU7, NK-1, NK-Cell marker, NK1
Reference Data

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