SPTAN1 Mouse Monoclonal Antibody [Clone ID: 3D7]

Specifications

Product Data
Clone Name	3D7
Applications	IF, WB
Recommend Dilution	Western Blot: 1/3000.  Immunofluorescence: 1/500.
Reactivity	Bovine, Human, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant construct containing the seventh, eighth and ninth repeats of human alpha II spectrin expressed in and purified from E. Coli.
Specificity	Specific for the ~240 k alpha II Spectrin protein.
Formulation	PBS State: Aff - Purified State: Liquid purified IgG fraction from Tissue Culture Supernatant. Preservative: 10mM Sodium Azide
Purification	Affinity Chromatography
Conjugation	Unconjugated
Storage Condition	Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Gene Name	spectrin, alpha, non-erythrocytic 1
Database Link	UniProt ID P07751
Background	The spectrin family of cytoskeletal proteins is comprised of 2 alpha genes (α1 and α2) and five beta genes (β1-β5). Spectrins have been shown to function as scaffolding proteins in mechanical support of the plasma membrane as well as bind other membrane proteins and lipids (Bennett and Baines 2001). Defects in spectrin genes have been linked to some forms of hereditary spherocytosis, a type of auto-hemolytic anemia which is characterized by spherical red blood cells that are more prone to lysis (Eber and Lux 2004).
Synonyms	Spectrin non-erythroid alpha chain, Alpha-II spectrin, Fodrin alpha chain, SPTA2
Reference Data

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