Gbgt1 (Forssman antigen) Rat Monoclonal Antibody [Clone ID: 117C9]

Specifications

Product Data
Clone Name	117C9
Applications	IHC
Recommend Dilution	Immunohistochemistry on Frozen sections.
Reactivity	Mouse
Host	Rat
Clonality	Monoclonal
Immunogen	The antibody 117C9 is a rat anti-Forrsman glycosphingolipid (FGL) antibody derived by fusing mouse myeloma cells with spleen cells from a Rat immunized with Mouse mammary tumors.
Specificity	Clone 33B12 and 117C9 detect overlapping epitopes on the Forssman glycolipid hapten (GalNA1- c3aG alNAcD1 -3GalaI-4GalB1-4GlcBl-lCer). Clone 117C9 recognizes the internal sugar sequence GalNAqYlBGal. The 117C9 antibody does not react exclusively with the Forssman antigen. In a lipid extract fractionated by Folch partition of Mouse mammary tumors the antibody also detects other glycolipid.
Formulation	PBS State: Purified State: Liquid purified Ig fraction Preservative: 0.09% Sodium Azide
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
Database Link	Entrez Gene 227671 Mouse UniProt ID Q8VI38
Background	The Forssman glycolipid is a glycosylceramide possessing a neutral pentasaccharide head group, referred to as the Forssman antigen (Fa) and is a member of the globoseries glycolipid family. Fa has been identified in a number of mammals and exhibits heterogeneity with respect to developmental and cell-type expression among species. Some studies have reported the presence of the Fa in certain human embryonic and tumor cells. The majority of human individuals have undetectable levels of Fa. Gastric and colonic tumors from Fa-negative patients, however, contained relatively high levels of Fa. Moreover, compared with normal lung tissue, many lung cancers contained elevated levels of Fa. These observations arouse interest in Fa for a possible role as a human tumor antigen.
Synonyms	A3GALNT; FS; MGC44848; UDP-GalNAc; UNQ2513
Reference Data

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