Integrin beta 4 (ITGB4) (1619-1822) Mouse Monoclonal Antibody [Clone ID: 10B10D5]

Specifications

Product Data
Clone Name	10B10D5
Applications	ELISA, FC, IHC, WB
Recommend Dilution	ELISA: 1/10000.  Western Blot: 1/500-1/2000.  Flow Cytometry: 1/200-1/400.  Immunohistochemistry on Paraffin Sections: 1/200-1/1000.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant fragment of Human ITGB4 (aa 1619-1822) expressed in E. Coli.
Specificity	This antibody recognizes Human ITGB4 (1619-1822). Other species not tested.
Formulation	State: Ascites State: Liquid Ascites Preservative: 0.03% Sodium Azide
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	202 kDa
Gene Name	integrin subunit beta 4
Database Link	Entrez Gene 3691 Human UniProt ID P16144
Background	Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Synonyms	ITGB4, GP150
Reference Data

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