CD45 (PTPRC) (CD45RB) Mouse Monoclonal Antibody [Clone ID: SPM569]
CAT#: AM33267PU-S
CD45 (PTPRC) (CD45RB) mouse monoclonal antibody, clone SPM569, Purified
Size: 20 ug
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CNY 5,606.00
货期*
4周
规格
Specifications
Product Data | |
Clone Name | SPM569 |
Applications | FC, IF, IHC |
Recommend Dilution | Flow Cytometry: 0.5-1 µg/106 cells. Immunofluorescence: 0.5-1 µg/ml. Immunohistochemistry on Formalin-Fixed Paraffin Sections: 0.5-1 µg/ml for 30 minutes at RT. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes. Positive Control: Ramos, U-698, or GA-10 cells, Tonsil. |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Human peripheral blood lymphocytes maintained in T cell growth factor. |
Specificity | This Monoclonal SPM569 antibody recognizes Human CD4RB5. Other species not tested. Cellular Localization: Cell surface and Cytoplasmic. |
Formulation | 10mM PBS State: Purified State: Liquid purified IgG fraction from Bioreactor Concentrate Stabilizer: 0.05% BSA Preservative: 0.05% Sodium Azide |
Concentration | lot specific |
Purification | Protein A/G Chromatography |
Conjugation | Unconjugated |
Storage Condition | Store undiluted at 2-8°C. |
Predicted Protein Size | 180-220 kDa |
Gene Name | protein tyrosine phosphatase, receptor type C |
Database Link | |
Background | CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms. |
Synonyms | PTPRC, Leukocyte common antigen, L-CA, T200 |
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